Focused on the traditional methods of feature selection for brain functional connectivity matrix derived from Resting-state functional Magnetic Resonance Imaging (R-fMRI) have feature redundancy, cannot determine the final feature dimension and other problems, a new feature selection algorithm was proposed. The algorithm combined Random Forest (RF) algorithm in statistical method, and applied it in the identification experiment of schizophrenic and normal patients, according to the features are obtained by the classification results of out of bag data. The experimental results show that compared to the traditional Principal Component Analysis (PCA), the proposed algorithm can effectively retain important features to improve recognition accuracy, which have good medical explanation.

Building an interpretable and large-scale protein-compound interactions model is an very important subject. A new chemical interpretable model to cover the protein-compound interactions was proposed. The core idea of the model is based on the hypothesis that a protein-compound interaction can be decomposed as protein fragments and compound fragments interactions, so composing the fragments interactions brings about a protein-compound interaction. Firstly, amino acid oligomer clusters and compound substructures were applied to describe protein and compound respectively. And then the protein fragments and the compound fragments were viewed as the two parts of a bipartite graph, fragments interactions as the edges. Based on the hypothesis, the protein-compound interaction is determined by the summation of protein fragments and compound fragments interactions. The experiment demonstrates that the model prediction accuracy achieves 97% and has the very good explanatory.